Genabelle PDRN: Rejuvenating Cream Ingredients and Evidence

Quick answer

Genabelle is a Korean skincare brand with a PDRN Rejuvenating range that includes a toner, ampoules, a cream and masks.[3] The brand says its story began in the treatment rooms of G.U. Clinic, founded by a doctor it calls Dr Conan.[2]

Its PDRN Rejuvenating Cream lists Sodium DNA and Hydrolyzed Sodium DNA in a moisturising base with niacinamide, panthenol, hyaluronic acid, peptides and ceramide NP, and it also contains fragrance.[1] It is a reasonable option if you want a hydrating PDRN moisturiser, but clinic origins and brand claims are not independent evidence that it works better than other PDRN creams.

In this guide

• Who makes Genabelle?
• The Genabelle PDRN range
• What is in the PDRN Rejuvenating Cream
• What Genabelle claims, and what the evidence shows
• Who it may suit, and who should be cautious
• Buying Genabelle in the UK
• Frequently asked questions
• References

Who makes Genabelle?

On its own website, Genabelle presents itself as a clinic-led brand that grew out of G.U. Clinic, founded by a doctor the site calls Dr Conan, who it says still uses the clinic to develop new products.[2] Its online store lists products under the vendor name Genalab USA.[1] We have not found independent verification of the brand's founding story or its clinical-record figures, so read them as brand marketing.

A clinic background is not, in itself, evidence for a cosmetic product. What matters for a cream is its finished formula and how your skin tolerates it.

The Genabelle PDRN range

Genabelle lists a Rejuvenating Toner, Rejuvenating Cream and sheet mask, as well as Vita Toning and Hyper Boost ampoules, an eye mask and sets.[3] Check the exact product and pack before comparing concentrations, because the numbers can refer to different ingredients or preparations.

What is in the PDRN Rejuvenating Cream

Genabelle lists the cream as 70 ml. Its published ingredient list includes:[1]

• Sodium DNA and Hydrolyzed Sodium DNA: the two DNA ingredients on the list. Genabelle states that the cream contains 1,000 ppm (0.1%) salmon DNA extract. That figure describes the extract as the brand reports it.[1]
• Humectants: glycerin, dipropylene glycol, sodium hyaluronate and hyaluronic acid, for hydration.
• Barrier-supporting ingredients: panthenol, ceramide NP and hydrogenated lecithin.
• Niacinamide and adenosine: commonly used for the look of uneven tone and fine lines.
• Peptides: tripeptide-1 and acetyl hexapeptide-8.
• Nucleobases: uracil, thymine, adenine, cytosine and guanine.
• Botanical extracts: centella asiatica, chamomile, portulaca and vitex agnus castus, plus evening primrose oil and beeswax.
• Fragrance: listed in the formula.

The full list on the brand's page is the version we checked on 5 November 2026. Always read the ingredient list on the product you receive.

What Genabelle claims, and what the evidence shows

Genabelle markets the cream as barrier-strengthening and "regenerative", powered by PDRN and a proprietary HTD-GENACOMPLEX.[1] It recommends the cream for dry and sensitised skin, dehydrated skin with a weakened barrier, and early signs of wrinkles or uneven tone.

We did not find an independently published study of this finished cream. Research in dermatology includes medical preparations, and early topical research has tested specific formulations that differ from this cream.[4][5] The ingredient list gives a plausible reason to expect hydration from the whole formula. It cannot tell us how much PDRN contributes. See what PDRN is and what it can do.

Who it may suit, and who should be cautious

It may suit people with dry, dehydrated or normal skin who want a moisturiser that includes PDRN alongside familiar hydrating and barrier ingredients.

Be cautious if you:

• React to fragrance: fragrance is listed, so patch test or choose a fragrance-free cream.
• Have a fish allergy or follow a vegan routine: the brand identifies salmon DNA extract, and the ingredient list includes beeswax.[1] If you have a fish allergy, ask your allergy clinician about using the exact product. See is PDRN vegan?.
• Have eczema, rosacea or very reactive skin: introduce one new product at a time.
• Are pregnant or breastfeeding: we did not find safety data for this cream in pregnancy or breastfeeding. Ask a midwife or pharmacist if unsure. See is PDRN safe in pregnancy?.

Buying Genabelle in the UK

Genabelle lists Skin Cupid in its UK retailer directory.[6] Check whether the retailer carries the 70 ml cream, then check the ingredient list on the pack you receive. Our guide to buying Korean skincare safely in the UK explains what to look for. For alternatives, compare PDRN creams and our best PDRN skincare in the UK picks.

Frequently asked questions

Is Genabelle a Korean brand?

Yes. Genabelle is sold as Korean skincare, and the brand says it started at G.U. Clinic.[2] Check the pack for the country of manufacture.

Does Genabelle PDRN cream contain fragrance?

Yes. Fragrance appears in the ingredient list on Genabelle's product page.[1]

Is Genabelle PDRN from salmon?

Genabelle describes its PDRN as salmon-derived, and the cream lists Sodium DNA and Hydrolyzed Sodium DNA.[1]

Is Genabelle better than other PDRN creams?

We did not find an independent comparison showing that. Compare the formulas, fragrance and texture with what you want from a moisturiser.

References

1. Genabelle. PDRN Rejuvenating Cream 70ml, product page and ingredient list, checked 5 November 2026.
2. Genabelle. G.U. Clinic, brand page, checked 5 November 2026.
3. Genabelle. Brand catalogue, checked 5 November 2026.
4. Kim ST. Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives. Pharmaceutics, 2025.
5. Ye R et al. Topical medium-length PDRN in photodamaged skin. PLOS One, 2026.
6. Genabelle. Authorised retailer directory, checked 5 November 2026.